General Information

  • ID:  hor000744
  • Uniprot ID:  Q5R4M6
  • Protein name:  Secretoneurin
  • Gene name:  SCG2
  • Organism:  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Family:  Chromogranin/secretogranin protein family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pongo (genus), Ponginae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  GO:0005576 extracellular region; GO:0030141 secretory granule

Sequence Information

  • Sequence:  TNEIVEEQYAPQSLATLESVFQELGKLTGPNNQ
  • Length:  33
  • Propeptide:  MAEAKTHWLGAALSLIPLIFLISGAEAASFQRNQLLQKEPDLRLENVKKFPSPEMIRALEYIEKLRQQAHKEESSSDYNPYQGVSVPFQQKENGDESHLPERDSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERKLKHMQFPPMNEENSRDNPFKRTNEIVEEQYAPQSLATLESVFQELGKLTGPNNQKRERMDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIEKNEQINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGERATRLFEKPLDSQSIYQLIEISRNLQIPPEDLIEMLKTGEKPNGSVEPERELDLPVDLDDISEADLDHPDLFQNKMLSKSGYPKTPGRAGTEALPDGLSVEDILNLLGMESAANQKTSYFPNPYNQEKVLPRLPYGPGRSRSNQLPKAAWMPYVENRQMAYENLNDKDQELGEYLARMLVKYPEIISSNQVKRVPGQSSSEDDLQEEEQIEQAIKEHLNQGSSQETDKLAPVSKRFPVGPPKNDDTPNRQYLDEDLLMKVLEYLNQEKAEKGREHIAKRAMENM
  • Signal peptide:  MAEAKTHWLGAALSLIPLIFLISGAEA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Regulate the biogenesis of secretory granules
  • Mechanism:  Binds calcium with a low-affinity.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q5R4M6-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000744_AF2.pdbhor000744_ESM.pdb

Physical Information

Mass: 421994 Formula: C159H251N41O57
Absent amino acids: CDHMRW Common amino acids: E
pI: 3.71 Basic residues: 1
Polar residues: 11 Hydrophobic residues: 10
Hydrophobicity: -61.82 Boman Index: -5517
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 82.73
Instability Index: 5566.97 Extinction Coefficient cystines: 1490
Absorbance 280nm: 46.56

Literature

  • PubMed ID:  NA
  • Title:  NA